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Tramadol
- Central analgesic
- Weak agonist of opioid receptors
- Inhibits noradrenaline, serotonin reuptake
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Pharmacokinetics
- Absorbed
from G. I. Tract
- Peak level - 15-45 minutes
- Metabolised in liver
- Excreted in urine
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Indications
Moderate to
severe pain
- Post operative pain, including orthopedic
surgery pain
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Dosage
50-100 mg 4
times daily
(Total daily dose should not exceed 400 mg)
Children
1-2 mg/kg body weight
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Adverse Effects
- Dizziness,
nausea, sedation, dry mouth, sweating
- Opioid related adverse effects e.g., constipation, respiratory depression,
are low with tramadol
Contraindications
- Hypersensitivity
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Precautions
- Concomitant
administration of alcohol, hypnotics,
CNS active drugs, MAO inhibitors
- Use of vehicles, complicated machinery
- Patients with decreased respiratory reserve, patients with
a history of seizures, myasthenia gravis
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Salient Features
- Opioid analgesic
- Centrally acting pain reliever
- Orally administered
- Useful for moderate to severe pain
e.g., post operative pain
- Better tolerability than other opioid analgesics
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