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Healthcare Communications

Tinidazole

 

Tinidazole

- Nitroimidazole derivative
- Structurally related to metronidazole and secnidazole

 

Spectrum Protozoa

- Entamoeba histolytica
- Giardia lamblia
- Trichomonas vaginalis
- Anaerobic bacteria

 

Pharmacology

- Rapid GI absorption
- Higher peak, longer half life than metronidazole
- Well distributed in the body
- Better tolerability profile than metronidazole

 

 

Brief comparison with metronidazole

  Metronidazole Tinidazole
Absorption
slower
faster
Peak conc
lower
higher
Half life
shorter
longer
Side effects
more
less
Usual dosage
t.d.s.
b.d.

 

 

Adverse Effects

- CNS & GI effects (nausea, dizziness, headache, dryness of mouth etc.)
- Antabuse like effect with alcohol
- Transient neutropenia, leucopenia

Contraindications

- Avoid in blood dyscrasias, neurological disorders
- Avoid in 1st trimester of pregnancy and in lactation

 

Indications

- Amoebiasis acute & chronic intestinal amoebiasis, hepatic amoebiasis
- Giardiasis
- Trichomoniasis
- Anaerobic bacterial infections

 

 

Dosage

Amoebiasis
- Usual dosage
2 grams daily for 3 days
- Children
10-15 mg/kg/day in 3 divided doses daily for 5-7 days

Giardiasis
Single 2 gram dose

Trichomoniasis
Single 2 gram dose

Anaerobic bacterial infection
Prophylactic 2 gm single dose before colorectal surgery

 

Comparison with metronidazole

- Reports indicate superior tolerability profile compared to metronidazole
- More convenient dosage schedule compared to metronidazole

 

 

Comparison with secnidazole

- Secnidazole is relatively poorly documented
- Tinidazole has time tested efficacy and safety