|
Tinidazole
|
Tinidazole
- Nitroimidazole
derivative
- Structurally related to metronidazole and secnidazole
|
Spectrum Protozoa
- Entamoeba
histolytica
- Giardia lamblia
- Trichomonas vaginalis
- Anaerobic bacteria
|
Pharmacology
- Rapid GI
absorption
- Higher peak, longer half life than metronidazole
- Well distributed in the body
- Better tolerability profile than metronidazole
|
Brief
comparison with metronidazole
| |
Metronidazole
|
Tinidazole
|
| Absorption |
slower
|
faster
|
| Peak
conc |
lower
|
higher
|
| Half
life |
shorter
|
longer
|
| Side
effects |
more
|
less
|
| Usual
dosage |
t.d.s.
|
b.d.
|
|
Adverse Effects
- CNS & GI
effects (nausea, dizziness, headache, dryness of mouth etc.)
- Antabuse like effect with alcohol
- Transient neutropenia, leucopenia
|
Contraindications
- Avoid in
blood dyscrasias, neurological disorders
- Avoid in 1st trimester of pregnancy and in lactation
|
Indications
- Amoebiasis
acute & chronic intestinal amoebiasis, hepatic amoebiasis
- Giardiasis
- Trichomoniasis
- Anaerobic bacterial infections
|
Dosage
Amoebiasis
- Usual dosage
2 grams daily for 3 days
- Children
10-15 mg/kg/day in 3 divided doses daily for 5-7 days
Giardiasis
Single 2 gram dose
Trichomoniasis
Single 2 gram dose
Anaerobic
bacterial infection
Prophylactic 2 gm single dose before colorectal surgery
|
Comparison
with metronidazole
- Reports indicate
superior tolerability profile compared to metronidazole
- More convenient dosage schedule compared to metronidazole
|
Comparison
with secnidazole
- Secnidazole
is relatively poorly documented
- Tinidazole has time tested efficacy and safety
|
|
