Norfloxacin
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Norfloxacin
- 4-quinolone
antibacterial
- Fluorinated piperazinyl-substituted congener of nalidixic acid
- Greater antibacterial activity compared to nalidixic acid
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Antibacterial
Spectrum
- E.coli
- Klebsiella
- Enterobacter
- Proteus
- Citrobacter
- H.influenzae
- N.gonorrhoeae, N.meningitidis
- Salmonella
- Shigella
- Staphylococci
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Pharmacokinetics
- 70% absorbed
after oral administration
- Absorption slightly delayed with food
- 400 mg oral dose gives 1.35-1.58 mg/l serum concentrations in 1-2
hours
- Good concentrations in kidney, prostate, urine, bile, faeces, vagina,
cervix, salpinges, ovaries
- 30% excreted unchanged in urine
- Metabolised in liver
- Elimination half life 3.5-6.5 hours
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Uses
1. UTI
- High urinary concentration
- Coverage of commonly involved organisms
- Coverage of Ps.aeruginosa; useful in catheter associated / nosocomial
infections
- No need to alkalinise the urine
- Does not disturb normal anaerobic bowel flora
- High cure rates
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Advantages
over other drugs in UTI
Nalidixic
acid
- Effective against bacteria resistant to nalidixic acid
- Broader spectrum, including Pseudomonas aeruginosa
- Resistance relatively rare
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Advantages over
other drugs in UTI (contd.)
Aminoglycosides
- Oral route of administration hence more convenient- Different chemical
group, hence effective against organisms resistant to aminoglycosides
- Avoids adverse effects of aminoglycosides, I.e., VIII cranial nerve
toxicity and nephrotoxicity
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Advantages over
other drugs in UTI (contd.)
Penicillins
(ampicillin, amoxycillin)
- Different chemical class, hence effective in cases resistant to penicillins
- Coverage of pseudomonas
- No plasmid mediated resistance
- May be used in patients allergic to penicillins
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Uses
(contd.)
2. Gonorrhoea
- Good activity against Neisseria gonorrhoea, including penicillinase
producers
- Good concentrations in genitourinary tract
- Single dose (800mg) therapy for uncomplicated gonorrhoea
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Uses
(contd.)
3. Gastrointestinal
Infections
- Good activity against Shigella, Salmonella, E.coli, Yersinia enterocolitica,
Campylobacter jejuni, Aeromonas hydrophilia, Pleismonas shigelloides
and Vibrio parahaemolyticus
- Poor activity against anaerobes, hence does not disturb normal anaerobic
bowel flora
- Good concentrations in stools
- Useful in bacterial diarrhoea, traveller’s diarrhoea, gastroenteritis
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Uses
(contd.)
4. In
Granulocytopenic patients
- Cytotoxic drugs (for cancer) may cause granulocytopenia
- In granulocytopenic patients, infections may occur arising from organisms
from the patient’s own gut
- Norfloxacin may be used for bowel decontamination
- Norfloxacin covers aerobic pathogens but spares normal anaerobic bowel
flora which helps in “colonisation resistance”
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Dosage
Usual
dosage
400 mg twice daily for 7-10 days
In
renal impairment (creatinine clearance < 30 ml/min)
400 mg daily
Chronic relapsing
UTI
400 mg twice daily for 10-21 days
Uncomplicated
gonorrhoea
800 mg single dose
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+Adverse
Effects
- Well tolerated
- Commoner effects are GI or neurological (nausea, headache, dizziness)
Contraindications/Precautions
- Contraindicated in hypersensitivity
- Adequate fluid intake advised to avoid crystalluria
- Avoid in children and in pregnancy, as damage to articular cartilage
has occurred in juvenile animals administered the drug
- Nitrofurantoin antagonises norfloxacin effect in urinary tract if
administered concurrently
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Comparison
with Ciprofloxacin
- Norfloxacin
is adequate for UTI, GI infections
- Ciprofloxacin is costlier Comparison with Nalidixic Acid
- Wider spectrum
- Less resistance
- Better penetration into tissues of urinary tract
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