Conventional NSAIDs (Non Steroidal Anti-Inflammatory Drugs) inhibit prostaglandin synthesis

Inhibition of prostaglandins necessary for gastric mucosal protection results in G.I. Adverse effects

 

 

 

Nimesulide

* Powerful Analgesic, Anti-Inflammatory, Antipyretic
* Selective cyclooxygenase (COX)inhibition minimises G.I. adverse effects

 

 

Mode of action

*Selective inhibition of COX-II (concerned with producing proinflammatory prostaglandins)
*No inhibition of COX-I (involved withcytoprotective prostaglandins). Thus minimal G.I. adverse effects

 

Tolerability

Well tolerated. Adverse effects 7% approx., mainly G.I. disturbances CNS and dermatological effects

Better G.I. tolerability. Less ulcerogenic potential and occult blood loss than most NSAIDs including diclofenac, indomethacin and piroxicam

No significant effect on blood chemistry. No nephrotoxicity

 

 

Contraindications

Pregnancy, lactation, hypersensitivity, active gastric ulcer or haemorrhage

 

Indications

Painful states and inflammatory states
e.g., Cancer related Pain, Trauma, Surgery
Rheumatic and Joint Diseases
e.g., Rheumatoid Arthritis, Ankylosing Spondylitis, Osteoarthritis, Periarthritis, Tendonitis, Bursitis
Gynaecological Conditions
e.g., Dysmenorrhoea, Pelvic Inflammatory Disease,
Urological conditions
e.g., Urethritis, Prostatitis, Vesiculitis
Others
e.g., Otitis, Rhinits, Thrombophlebitis, Sinusitis, Pharyngitis, Bronchitis

 

Dosage and Administration

Adults
100-200 mg twice daily

Children (< 12 years )
1.5 mg/kg/day in acute inflammatory disorders of the airways; 50 mg twice daily in soft tissue injuries.