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Healthcare Communications



Conventional NSAIDs (Non Steroidal Anti-Inflammatory Drugs) inhibit prostaglandin synthesis

Inhibition of prostaglandins necessary for gastric mucosal protection results in G.I. Adverse effects





* Powerful Analgesic, Anti-Inflammatory, Antipyretic
* Selective cyclooxygenase (COX) inhibition minimises G.I. adverse effects



Mode of action

*Selective inhibition of COX-II (concerned with producing proinflammatory prostaglandins)
*No inhibition of COX-I (involved with cytoprotective prostaglandins). Thus minimal G.I. adverse effects








Well tolerated. Adverse effects 7% approx., mainly G.I. disturbances CNS and dermatological effects

Better G.I. tolerability. Less ulcerogenic potential and occult blood loss than most NSAIDs including diclofenac, indomethacin and piroxicam

No significant effect on blood chemistry. No nephrotoxicity




Pregnancy, lactation, hypersensitivity, active gastric ulcer or haemorrhage



Painful states and inflammatory states
e.g., Cancer related Pain, Trauma, Surgery
Rheumatic and Joint Diseases
e.g., Rheumatoid Arthritis, Ankylosing Spondylitis, Osteoarthritis, Periarthritis, Tendonitis, Bursitis
Gynaecological Conditions
e.g., Dysmenorrhoea, Pelvic Inflammatory Disease,
Urological conditions

e.g., Urethritis, Prostatitis, Vesiculitis
e.g., Otitis, Rhinits, Thrombophlebitis, Sinusitis, Pharyngitis, Bronchitis


Dosage and Administration

100-200 mg twice daily

Children (< 12 years )
1.5 mg/kg/day in acute inflammatory disorders of the airways; 50 mg twice daily in soft tissue injuries.